Effect of B complex vitamins on life quality and neuropathic pain intensity in patients undergoing hemodialysis
DOI:
https://doi.org/10.71152/ajms.v13i3.3935Keywords:
Chronic pain, Chronic renal failure, Drug therapy, Pain, Quality of lifeAbstract
Background: Neuropathic pain (NP) is characterized by chronic pain with a generally strong intensity that leads to limitations regarding activities of daily living.
Aims and Objectives: The aim of the study was to investigate the effect of B complex vitamins on NP intensity and life quality in patients undergoing hemodialysis.
Materials and Methods: A randomized controlled double-blind clinical trial was conducted among hemodialysis patients with clinical diagnosis of NP randomly allocated to two groups: A (gabapentin) and B (B vitamins). DN4, visual analog scale, and Kidney Disease Quality of Life-Short Form questionnaire were used to identify NP, measure pain intensity, and assess quality of life, respectively.
Results: A significant reduction in pain occurred after treatment with gabapentin (P=0.003). In the B group, the reduction of pain went from a mean of 7.27 to 5.09 after treatment (P=0.056). In the A group, a significantly poorer quality of life was reported after treatment in the social relations domain (P=0.010). A significant improvement in quality of life and environment domains (P=0.025 and 0.049, respectively) was reported after use of B vitamins.
Conclusion: These findings demonstrate that B complex vitamins for the treatment of NP in hemodialysis patients should be investigated further, as this form of treatment contributed to a reduction in pain intensity and suffering with no side effects and at low cost.
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