Prevalence and antifungal susceptibility of invasive Candida species among hospitalized patients: A cross-sectional study in Vietnam
DOI:
https://doi.org/10.71152/ajms.v16i8.4584Keywords:
Candida spp.; invasive fungal infection; Antifungal resistanceAbstract
Background: Invasive Candida infections are a major cause of illness and death in hospitalized patients. This is, especially true for that in intensive care or with serious health issues. Antifungal resistance is rising, making treatment more difficult.
Aims and Objectives: To find the prevalence and antifungal resistance patterns of invasive Candida species from inpatients at the National Hospital for Tropical Diseases between January and June 2024.
Materials and Methods: We conducted a cross-sectional study with 270 inpatients who had confirmed invasive Candida infections. We identified 342 isolates and tested them for antifungal resistance using the VITEK 2 Compact system. We extracted data from medical records and lab results and then analyzed it using the Statistical Package for the Social Sciences 25.0.
Results: Among the 342 clinical isolates, Candida albicans was the most common at 52.3%. This was followed by Candida tropicalis (30.1%), Candida glabrata (10.8%), and Candida parapsilosis (4.1%). Resistance testing showed Echinocandins was highly effective. In contrast, Fluconazole had high resistance rates, especially in C. tropicalis (27.3%) and C. parapsilosis (42.9%).
Conclusion: C. albicans and C. tropicalis were the most prevalent species. Echinocandins and Amphotericin B are still effective first-line treatments. However, caution is needed with Azoles. Early screening for high-risk patients is crucial for timely diagnosis and management.
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