The correlation of neutrophil-lymphocyte ratio and platelet–lymphocyte ratio with nephropathy in patients of type 2 diabetes mellitus-a hospital-based study from South India
DOI:
https://doi.org/10.71152/ajms.v16i7.4615Keywords:
Neutrophil–lymphocyte ratio; Platelet–lymphocyte ratio; Diabetic nephropathy; Type 2 diabetes mellitusAbstract
Background: Diabetes is a group of metabolic diseases characterized by hyperglycemia due to defects in insulin secretion, action, or both. Diabetic nephropathy is among the serious complications of diabetes. Albuminuria is used as a biomarker for diabetic nephropathy. There is evidence of inflammation leading to the development and progression of diabetic nephropathy. White blood cell count, platelet counts have been used as markers of inflammation.
Aims and Objectives: This study aims to determine a correlation between neutrophil-lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and diabetic nephropathy.
Materials and Methods: This cross-sectional analytical study was done among 99 individuals availing of the Medical College Hospital services for 18 months. They were classified into three groups of thirty-three participants each, based on the urine albumin–creatinine ratio. The three groups were the normoalbuminuria, microalbuminuria, and macroalbuminuria groups. The NLR and PLR was calculated and compared among the three groups.
Results: The mean NLR in diabetic patients with macroalbuminuria (2.68) was significantly higher than patients with normoalbuminuria (1.46) and microalbuminuria (1.80) (P=0.001). The mean PLR was also higher in diabetic patients with macroalbuminuria (156.80) when compared to patients with normoalbuminuria (90.94) and microalbuminuria (119.03) (P=0.001).
Conclusions: Increased NLR and PLR levels are associated with diabetic nephropathy. A higher NLR and PLR value can indicate the progression of diabetic nephropathy due to worsening estimated glomerular filtration rate. NLR and PLR can be used as a simple prognostic marker for Diabetic Nephropathy.
Downloads
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Asian Journal of Medical Sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Authors who publish with this journal agree to the following terms:
- The journal holds copyright and publishes the work under a Creative Commons CC-BY-NC license that permits use, distribution and reprduction in any medium, provided the original work is properly cited and is not used for commercial purposes. The journal should be recognised as the original publisher of this work.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
