Oxidative stress and primary open-angle glaucoma: A correlative study of serum bilirubin, albumin, and thiobarbituric acid reactive substance
DOI:
https://doi.org/10.71152/ajms.v16i9.4660Keywords:
Bilirubin; Albumin; Antioxidant; Thiobarbituric acid reactive substance; Advanced oxidative protein product; Oxidative stress; Primary open angle glaucomaAbstract
Background: Primary open-angle glaucoma (POAG) is a major health burden throughout the world. The imbalance between antioxidant defence and pro-oxidant plays an important role in this multifactorial disorder. Few recent studies have shown that serum total bilirubin and albumin play an important role in POAG.
Aims and Objectives: The aim of the study was to estimate serum albumin, total bilirubin, thiobarbituric acid reactive substances (TBARS), and advanced oxidative protein products (AOPP) in POAG cases and controls and find out the association between serum total bilirubin, albumin with TBARSs.
Materials and Methods: The study was conducted in the department of Biochemistry, Calcutta National Medical College, Kolkata, after getting ethical clearance. Fifty-five cases and 55 comparisons were taken. Samples were processed, and tests were performed.
Results: It showed that the mean intraocular pressure in the case is 22.51±1.77 mm of Hg much higher than the comparison group 13.78±1.49 mm of Hg. Serum total bilirubin and serum albumin were significantly decreased in POAG cases. Serum TBARS and serum AOPP were significantly increased in POAG cases. Spearman’s rho correlation showed that there was a significantly negative correlation between TBARS and total bilirubin (r=−0.370). Spearman’s rho correlation showed that there was a significant positive correlation between serum AOPP and TBARS (r=0.556). Spearman’s rho correlation showed that there was a negative correlation between serum albumin and TBARS (r=−0.076, which was statistically not significant P=0.428).
Conclusion: Oxidative stress plays an important role in POAG. Bilirubin and albumin, through their antioxidant and anti-inflammatory action, try to prevent the progression of POAG.
Downloads
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Asian Journal of Medical Sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Authors who publish with this journal agree to the following terms:
- The journal holds copyright and publishes the work under a Creative Commons CC-BY-NC license that permits use, distribution and reprduction in any medium, provided the original work is properly cited and is not used for commercial purposes. The journal should be recognised as the original publisher of this work.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
